Insulin resistance is when the body produces insulin but does not use it properly. Insulin is a hormone made in the beta cells of the pancreas. It helps the glucose in your blood enter your cells to be used as energy. Type 2 diabetes occurs when your body's cells become resistant to insulin, leaving high amounts of glucose circulating in the blood, which can damage your organs and raise your risk of cardiovascular disease. People who are overweight and obese, have high belly fat, and are generally inactive are at increased risk of developing insulin resistance.