Buying a test for someone else?
Learn how
UK's first direct-to-consumer blood testing service. 
We've delivered over 7.5 million test results. 
We've helped over 200,000 people take control of their health. Biomarker table
Autoimmunity
Anti CEN - P Antibodies
Learn more
Anti Jo1 Antibodies
Learn more
Anti La SS - B Antibodies
Learn more
Anti Ro SS - A Antibodies
Learn more
Anti Scl 70 Antibodies
Learn more
Anti Sm Antibodies
Learn more
Anti U1RNP Antibodies
Learn more
Extractable nuclear antigen
Learn more
An extractable nuclear antigen (ENA) screen looks for the presence of one or more autoantibodies in the blood that react with proteins in the cell nucleus. Autoantibodies are produced when the immune system mistakenly targets and attacks the body's own tissues which can cause inflammation, tissue damage and symptoms associated with an autoimmune disorder. The results of an ENA screen can help to detect and distinguish between different autoimmune disorders.
Blood testing made easy
How it works
Your personalised, actionable health results are only a few clicks away. Order your test, take and post your sample, then view your results online with our doctors' comments.
Your results, simplified
Track, improve, and monitor your health over time
MyMedichecks is your personal online dashboard where you can view your results, access clear and simple explanations about individual health markers, monitor changes in your health, and securely store information about your medical history, lifestyle, and vital statistics.
FAQs
What tests are included?
This panel includes tests for different antibodies, including:
- -Anti-RNP antibodies to detect mixed connective tissue disease (MCTD)
- -Anti-Sm antibodies for systemic lupus erythematosus (SLE)
- -Anti-SS-A (Ro) and anti-SS-B (La) antibodies for Sjögren's syndrome
- -Scl-70 antibodies for scleroderma (systemic sclerosis)
- -Anti-Jo-1 for polymyositis
Titre levels are only provided for positive results.
Who should take this test?
This test is usually requested following a positive ANA test for people with signs and symptoms of an autoimmune disorder.
What is an ENA blood test?
Our Extractable Nuclear Antibodies (ENA) Blood Test detects the presence of one or more autoantibodies in the blood that react with proteins in the cell nucleus.
Limitations of the test
Read before you order:
A positive ENA result is suggestive but not conclusive for connective tissue disease. Your result should be interpreted alongside your symptoms, medical history, and other investigations. A false-positive result (a result that suggests connective tissue disease when there is none) is more common in people with other underlying autoimmune conditions.
False-negative results are also possible, and usually occur in the early stages of disease when antibody levels are below detectable levels.
An ENA blood test result can’t give information about current disease activity or the severity of the condition.