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Intrinsic Factor Antibodies


Intrinsic factor is produced in the stomach and helps extract vitamin B12 from the foods we eat. Interference in its production or activity can reduce the absorption of vitamin B12. Intrinsic factor antibodies are produced by the immune system and and is necessary to extract vitamin B12 from the food we eat. Without sufficient intrinsic factor available, vitamin B12 is unabsorbed and the body cannot produce enough red blood cells which leads to the autoimmune condition pernicious anaemia.

What might a high result mean?

The presence of intrinsic factor antibodies alongside a decreased vitamin B12 level and/or increased methylmalonic acid and homocysteine levels indicates pernicious anemia is likely.