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Gastric Parietal Cell Antibodies


Parietal cell antibodies are autoantibodies, produced by the immune system that mistakenly target and destroy parietal cells, specialised cells in the stomach that aid digestion and make intrinsic factor. Intrinsic factor is required for the absorption of vitamin B12 from food. The progressive loss of parietal cells may lead to a vitamin B12 deficiency.

Gastric parietal cells antibodies are associated with autoimmune gastritis and pernicious anaemia. This test helps to find out more about the cause of a vitamin B12 deficiency.

What might a high result mean?

A positive result may indicate that a vitamin B12 deficiency could be due to pernicious anaemia - an autoimmune disease. However, The parietal cell antibody test alone should not be used to diagnose this condition.