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Creatinine Clearance


Creatinine clearance is a measure of kidney function. It is calculated by collecting all the urine passed over 24 hours, then analysing how much creatinine is within it. For most people the estimated glomerular filtration provides a more convenient means of assessing kidney health.

What might a low result mean?

Creatinine is a chemical waste molecule that is generated from normal muscle metabolism. Creatinine clearance evaluates the rate and efficiency of kidney filtration. It helps to investigate kidney dysfunction resulting from either kidney disease or decreased blood flow to the kidneys.

A creatinine clearance test compares the level of creatinine in urine with the creatinine level in the blood to work out how much creatinine has been cleared from the blood and passed into the urine. This result reflects how much blood is being filtered through the the kidneys in a 24-hour time period to assess kidney function.

What might a high result mean?

A low creatinine clearance result may indicate a problem with the kidneys due to disease within the kidney cells or because of less blood getting to the kidneys. Diabetes, a blockage within the kidney and kidney disease are all possible causes.